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QUEBEC METABOLIC PHENOTYPING CORE

Located at the Quebec Heart and Lung Institute, the Quebec Metabolic Phenotyping Core (QMPC) provides specialized services that are essential in phenotyping pre-clinical models with metabolic diseases and a unique pipeline for neurometabolic pharmacology.

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Core director
Alexandre Caron, PhD

OUR SERVICES

Energy metabolism

  • Indirect calorimetry

  • Temperature-controlled environment

  • Body temperature (telemetry)

  • Locomotor activity

  • Cold tolerance

  • Circadian rhythm

  • Bomb calorimeter

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Glucose metabolism

  • Glucose tolerance test

  • Insulin tolerance test

  • Lactate-pyruvate tolerance test

  • In vivo insulin signaling

  • In vivo glucose uptake assay

  • Continuous glucose monitoring (telemetry)

 

Lipid metabolism

  • In vivo fatty acid uptake assay

  • In vivo & ex vivo lipolysis

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Neurometabolism

  • Patch-clamp electrophysiology

  • Osmolarity

  • Robot Stereotaxic System

  • In situ hybridization

  • Sleep staging (Electroencephalogram & Electromyography)

 

Drug discovery

  • Pipelines for drug repositioning

  • Hybrid Multimode Microplate Reader with injectors (BRET/FRET/ELISA)

  • Liver Perfusion System

  • Primary hepatocytes

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